| President: |  Fr. Roberto Tucci, S.J. (later Cardinal) (1985 – 2001) |
| Director General: | Fr. Federico Lombardi, S.J. (2005.11.05 – 2016.03.01) |
| Director General: | Fr. Pasquale Borgomeo, S.J. (1985.07 – 2005.11.05) |
| Director General: | Fr. Roberto Tucci, S.J. (later Cardinal) (1973 – 1985) |
| Director General: | Fr. Giacomo Martegani, S.J. (1967 – 1973) |
| Director General: | Fr. Antonio Stefanizzi, S.J. (1953 – 1967) |
| Director General: | Fr. Filippo Soccorsi, S.J. (1934 – 1953) |
| Director General: | Fr. Giuseppe Gianfranceschi, S.J. (1931 – 1934) |
| Director of Administration: | Dr. Giacomo Ghisani (54) (2016.03.01 – 2016) |
| Director of Administration: | Dr. Alberto Gasbarri (2001? – 2016.03.01) |
| Program Director: |  Fr. Andrzej Majewski, S.J. (2015.09.29 – 2016) |
| Program Director: | Fr. Andrzej Koprowski, S.J. (2005.11.05 – 2015.09.29) |
| Program Director: | Fr. Federico Lombardi, S.J. (1991 – 2005.11.05) |
(x 2)