| Consistory of 1644.11.14 (at the time of creation) (4) |
| 1. |  Mr. Camillo Francesco Maria Pamphilj (22) | Cardinal-Deacon |
| 2. | Mr. Giancarlo de’ Medici (33) | Cardinal-Deacon |
| (3) | Mr. Domenico Cecchini (55) | Cardinal-Priest |
| (4) | Mr. Francesco Maria Farnese (25) | Cardinal-Deacon |
| Consistory of 1645.03.06 (at the time of creation) (7) |
| 1. |  Archbishop-elect Niccolò Albergati Ludovisi (36), Metropolitan Archbishop of Bologna (Italy) | Cardinal-Priest |
| 2. |  Bishop Tiberio Cenci (65), Bishop of Jesi (Italy) | Cardinal-Priest |
| 3. | Bishop Pier Luigi Carafa (63), Bishop of Tricarico (Italy) and Prefect of Sacred Congregation of the Council | Cardinal-Priest |
| 4. | Bishop Orazio Giustiniani, C.O. (67), Bishop of Nocera Umbra (Italy) | Cardinal-Priest |
| 5. |  Msgr. Alderano Cibo-Malaspina (31), Prefect of Prefecture of the Holy Apostolic Palaces and Master of Papal Chamber of Prefecture of the Holy Apostolic Palaces | Cardinal-Priest |
| 6. |  Fr. Federico Sforza (42) | Cardinal-Deacon |
| 7. | Mr. Benedetto Odescalchi (33) | Cardinal-Deacon |
| Consistory of 1646.05.28 (at the time of creation) (1) |
| 1. |  Fr. Jan Kazimierz Wazy, S.J. (36) | Cardinal-Priest |
| Consistory of 1647.10.07 (at the time of creation) (7) |
| 1. | Archbishop Fabrizio Savelli (40), Metropolitan Archbishop of Salerno (Italy) | Cardinal-Priest |
| 2. |  Archbishop Michel Mazarin, O.P. (42), Metropolitan Archbishop of Aix (France) | Cardinal-Priest |
| 3. | Fr. Francesco Cherubini (62) | Cardinal-Priest |
| 4. | Mr. Cristoforo Vidman (30) | Cardinal-Deacon |
| 5. | Fr. Lorenzo Raggi (32) | Cardinal-Deacon |
| 6. | Mr. Francesco Maidalchini (26) | Cardinal-Deacon |
| (7) |  Mr. Antonio de Aragón-Córdoba-Cardona y Fernández de Córdoba (32) | Cardinal-Deacon |
| Consistory of 1650.09.19 (at the time of creation) (1) |
| 1. | Fr. Camillo Astalli-Pamphili (31) | Cardinal-Priest |
| Consistory of 1652.02.19 (at the time of creation) (12) |
| 1. |  Archbishop Jean-François-Paul de Gondi de Retz (38), Titular Archbishop of Corinthus and Coadjutor Archbishop of Paris (France) | Cardinal-Priest |
| 2. | Archbishop Domingo Pimentel Zúñiga, O.P. (67), Metropolitan Archbishop of Sevilla (Spain) | Cardinal-Priest |
| 3. | Bishop Fabio Chigi (52), Bishop of Nardò (Italy) | Cardinal-Priest |
| 4. | Msgr. Giovanni Girolamo Lomellini (43), Treasurer General of Reverend Apostolic Camera | Cardinal-Priest |
| 5. | Fr. Luigi Omodei (45) | Cardinal-Priest |
| 6. | Fr. Pietro Vito Ottoboni (41) | Cardinal-Priest |
| 7. | Fr. Giacomo Corradi (50) | Cardinal-Priest |
| 8. | Fr. Marcello Santacroce (32) | Cardinal-Priest |
| 9. | Fr. Baccio Aldobrandini (38) | Cardinal-Priest |
| 10. | Fr. Friedrich von Hessen-Darmstadt, O.E.S.S.H. (35) | Cardinal-Deacon |
| (11) | Mr. Lorenzo Imperiali (39) | Cardinal-Priest |
| (12) | Mr. Giberto Borromeo (36) | Cardinal-Priest |
| Consistory of 1653.06.23 (at the time of creation) (1) |
| 1. | Mr. Carlo Barberini (22) | Cardinal-Deacon |
| Consistory of 1654.03.02 (at the time of creation) (7) |
| 1. |  Patriarch Giovanni Battista Spada (56), Patriarch of Constantinople and Vice-Camerlengo of the Holy Roman Church emeritus of Reverend Apostolic Camera | Cardinal-Priest |
| 2. | Fr. Propsero Caffarelli (62) | Cardinal-Priest |
| 3. | Fr. Francesco Albizzi (60) | Cardinal-Priest |
| 4. | Fr. Ottavio Acquaviva d’Aragona (44) | Cardinal-Priest |
| 5. | Fr. Carlo Pio di Savoia (31) | Cardinal-Deacon |
| 6. | Mr. Carlo Gualterio (40) | Cardinal-Deacon |
| 7. | Mr. Decio Azzolini (30) | Cardinal-Deacon |
(40)
